Cochrane review (2015) – included a total of 33 RCTs, accounting for 4268 hospitalised patients with sepsis. Three trials included children, and the remaining 30 trials included only adults. Corticosteroids were compared with placebo in all except five trials, in which they were compared with standard therapy alone. Low-quality evidence indicates that steroids reduce mortality among patients with sepsis. Moderate-quality evidence suggests that a long course of low-dose steroids reduced 28-day mortality without inducing major complications.