Pain after a corticosteroid injection is not the norm, but it’s not abnormal either. I can’t speak to your situation, but I can say that occasionally patients will have what’s called “post injection flare” where the pain is worse for 2-3 days after the injection. I would tell patients to put ice on the area and as long as it’s not red, swollen or with discharge at the injection site, sit on it for a couple days to see if it resolves. If it’s not any better after 2-3 days, then come into the office. And just so you know, it does NOT mean the injection did or did not work correctly, and it does not matter which technique was used to get the steroid into the knee joint.
Appropriate treatment with antibiotics can be very beneficial to Lyme disease pain. Additional medications used to manage the pain from chronic Lyme disease include non-steroidal anti-inflammatories, anticonvulsants, antidepressants, opioids, and muscle relaxants. Additional treatments include "restorative" yoga, enzymes, essential oils, prolotherapy, injections, relaxation, manual treatments and gentle exercises. Some patients use magnets, tens machines and creams. Oftentimes chiropractic (many types), physical therapy (multiple techniques) and acupuncture are extremely beneficial, although it can be trial and error to find the right practitioner who can be flexible to the variable needs of Lyme patients.