Steroidogenesis pathway animation

Calnexin is encoded by the CNX gene and is a transmembrane protein chaperone associated with the ER. The function of calnexin is to assist in the folding of N-glycosylated proteins within the ER. The function of calnexin ensures that only glycoproteins that are properly folded and assembled continue further along the secretory pathway . Calnexin only binds to N-glycoproteins that have a Glc 1 Man 9 GlcNAc 2 oligosaccharide attached to an Asp residue. This structure results from glucosidase actions on the en bloc oligosaccharide (Glc 3 Man 9 GlcNAc 2 ) catalyzed first by glucosidase I (GluI) and then by glucosidase II (GluII). GluI is encoded by the mannosyl-oligosaccharide glucosidase (MOGS) gene. Functional GluII is composed of an α-subunit and a β-subunit. The GluII α-subunit gene is GANAB (glucosidase II alpha subunit) and the β-subunit gene is PRKCSH (protein kinase C substrate 80K-H). Calreticulin is encoded by the CALR gene. Calreticulin is a multifunctional protein whose primary function is to bind and sequester Ca 2+ ions in the lumen of the ER. Calreticulin also binds to misfolded proteins preventing them from being exported from the ER to the Golgi apparatus.

Steroidogenesis pathway animation

steroidogenesis pathway animation

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