Due to the hepatotoxic nature of some anabolic steroids, primarily oral steroids, when such steroids are used your liver enzyme values will increase due to the stress on the liver. The hepatotoxic nature of the steroid will vary from one to the next, often tremendously, and as you may have guessed there are several important notes. If we supplement responsibly, assuming our liver was healthy to begin with it is very unlikely any permanent damage will be done; in most case, once all C17-aa steroids have been discontinued your liver enzyme values will return to normal. In-order to achieve this successful end, it is imperative you avoid heavy alcohol consumption when supplementing with C17-aa steroids, as this is far more stressful to the liver; in-fact, it's probably not a bad idea to avoid alcohol altogether. This really shouldn't be all that hard to do; after all, one of the main reasons people supplement with anabolic steroids is to improve their physique, and alcohol, in no way, promotes this end. Further, avoiding all over the counter (OTC) medications where possible is highly advised, as many OTC medications are far more toxic to the liver than the vast majority of anabolic steroids. This does not mean you cannot use any OTC medications, but they should be few and far-between, and only when absolutely necessary. Last but certainly not least, when supplementing with C17-aa steroids use should in most cases be limited to 6 weeks; if it's an extremely hepatotoxic steroid 4 weeks should be the max with mild steroids being acceptable for 8 weeks. These time frames do not mean your total cycle cannot extend past these points of use; it simply means this should be the maximum time frame of C17-aa steroid use. If you can do these things, if your liver was healthy before supplementation began and you supplemented with responsible doses most all will find their liver to be unharmed. If you do not head to all this advice, you may find you severely damage one of the most important organs your body desperately needs; no, you do not have to supplement with C17-aa steroids to garner success, but if you do you should head these notes of caution.
Acne is often present. Acne conglobata is a particularly severe form of acne that can develop during steroid abuse or even after the drug has been discontinued. Infections are a common side effect of steroid abuse because of needle sharing and unsanitary techniques used when injecting the drugs into the skin. These are similar risks to IV drug abusers with increased potential to acquire blood-borne infections such as hepatitis and HIV/AIDS . Skin abscesses may occur at injection sites and may spread to other organs of the body. Endocarditis or an infection of the heart valves is not uncommon.
During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.