Glucocorticosteroids

Thank you for your quick response in this forum, looks like no has posted for a while. I guess i was hoping for some explanation of the Salt Cravings and yet Edema, i was under the assumption that the Salt Carvings came from Low Aldosterone, where as the Edema came from High Aldosterone, so you can see my confusion.
I already have seen an Endo, twice and they dont seem to be concerned – ALL my Blood Tests are sooooo good the only thing that came back a little high was the Insulin, but that is normal with Adrenal Fatigue i have been told.
I have learned that high Insulin can cause water retention, so perhaps that is an issue here, but the thing about that is… i have had high insulin for years and stayed slim, however after the Adrenal Fatigue got worse, the Water Retention started and so i connect the Renin/Angiotensin/Aldosterone thing to that maybe.
I dont get any sun and do not take Vit D and i read that Vit D is helpful in the Renin process.

Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2 , thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events ( epithelial adhesion , emigration , chemotaxis , phagocytosis , respiratory burst , etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes . They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase /PGE isomerase (COX-1 and COX-2), [29] the latter effect being much like that of NSAIDs , potentiating the anti-inflammatory effect.

Glucocorticosteroids

glucocorticosteroids

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