Cardiovascular risk factors include the alteration or diminishing of her glucose tolerance and hyperinsulinism (become resistant to insulin), a change in lipoproteins (carry cholesterol in blood) fraction which can cause cardiovascular disease and atherosclerosis (deposition of fatty substances onto inner walls of arteries causing blockage), increased triglyceride levels, hypertension (abnormally high blood pressure), changes in her myocardium (middle muscular layer of heart wall), and increased concentration levels of several different clotting factors. Cardiomyopathy (a typically chronic disorder of heart muscle that may involve hypertrophy and obstructive damage to the heart), myocardial infarction (localized death of the myocardium tissue usually leading to heart failure), heart attack, stroke, and cerebro-vascular accidents have all been causes in deaths where AAS abuse was implicated. Of course the liver, the body’s primary filtration system will come under attack as it has to accommodate the increased toxicity. Among the liver problems promoted are holestatic jaundice (failure of bile flow that causes yellowish pigmentation of skin, tissues, and body fluids), peliosis hepatis (blood-filled cysts develop on liver), hepatocellular hyperplasia (unusual increase of an epithelial parenchymatous cell called hepatocytes in the liver), and cancer. Secondary filters such as the kidneys and gallbladder also become more susceptible to disease.
Author: Samuel J Haraldson, MD, Sports Medicine Fellow, Department of Sports Medicine, UT Southwestern/Methodist Charlton Hospital.
Coauthor(s): Barbara J Blasko, MD, Clinical Assistant Professor, Department of Emergency Medicine, University of California at Irvine College of Medicine.
Editors: Scott H Plantz, MD, FAAEM, Research Director, Assistant Professor, Department of Emergency Medicine, Mount Sinai School of Medicine; Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine; Thomas Rebbecchi, MD, FAAEM, Program Director, Assistant Professor, Department of Emergency Medicine, University of Medicine and Dentistry of New Jersey.
Reviewing this season, DVD Verdict said, "There are some real clinkers this season. Both "Large Marge" and "Strong Arm of the Ma" prove that writing good episodes about Marge seem to be out of the question by this point."  describes the premise as "Marge becomes agoraphobic (yes, only for one episode) after being mugged on the street and rather strangely decides that the best thing to do is take up weight lifting. It’s just a silly as it sounds. Another dud of an episode.  DVD Talk said, "What's encouraging is that the 300th episode, whether it's "Barting Over" or "Strong Arms of the Ma," is simply a number to the writers and producers of The Simpsons at this point, rather than a finish line."