3alpha hydroxysteroid dehydrogenase deficiency

Abrupt withdrawal of cyproterone acetate can be harmful, and the package insert from Schering AG recommends that the daily dose be reduced by no more than 50 mg, at intervals of several weeks. The primary concern is the manner in which cyproterone acetate affects the adrenal gland. Due to its glucocorticoid activity, high levels of cyproterone acetate may reduce ACTH , resulting in adrenal insufficiency if discontinued suddenly. In addition, although cyproterone acetate reduces androgen production in the gonads, it can increase adrenal androgen production, in some cases resulting in an overall rise in testosterone levels. [20] Thus the sudden withdrawal of cyproterone acetate may result in undesirable androgenic effects. This is a particular concern because androgens, especially DHT , suppress adrenal function, further reducing cortisol production. [21] In theory, 5-alpha-reductase inhibitors such as finasteride and dutasteride may be able to mitigate this effect somewhat by preventing the conversion of testosterone to the more potent DHT.

Amongst some of the supplements and substances historically reporting to have a lowering effect are: Vitamin C, rutin, forskolin, fish oil and a few others. The most well studied has been vitamin C, but when it did have an effect, it was via large intravenous dosages, and the effect is believed to have been because of fluid or osmotic changes. However in spite of the above, we include here a few substances which because of scientific studies, may prove to have some benefit to the physiology of the Trabecular meshwork (drain of the eye), and therefore, may help regulate eye pressure. It is also quite possible that some see an effect on eye pressures even though others may not. You might also find two blog posts by Dr Robert Ritch   Non-pharmaceutical medications and approaches to glaucoma  and Complementary Therapy for the Treatment of Glaucoma informative.

3alpha hydroxysteroid dehydrogenase deficiency

3 alpha hydroxysteroid dehydrogenase deficiency

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